Genetic engineering: Human insulin

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Genetic engineering in mice: impact on insulin signalling and action.

The expression of a number of genes encoding key players in insulin signalling and action, including insulin, insulin receptor (IR), downstream signalling molecules such as insulin receptor substrate-1 (IRS-1) and IRS-2, glucose transporters (GLUT4, GLUT2) and important metabolic enzymes such as glucokinase, has now been altered in transgenic or knockout mice. Such mice presented with phenotype...

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ژورنال

عنوان ژورنال: Nature

سال: 1982

ISSN: 0028-0836,1476-4687

DOI: 10.1038/300100c0